2027 NCODA Global Oncology & Haematology Congress
March 10, 2027 | 9:00 AM EST
Shifting Treatment Perspectives in Polycythemia Vera Real-World Experience with Ropeginterferon Alfa-2b
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Prepared by Michelle Taymuree, PharmD, MBA, and NCODA for PharmaEssentia | August 2026
Is Polycythemia Vera Treatment Practice Keeping Pace with the Evidence?
The treatment landscape for polycythemia vera (PV) is evolving, with growing emphasis on long-term disease control, earlier use of interferon-based therapy, and individualized treatment strategies. But translating these advances into everyday practice can bring real operational and patient-care challenges.
This white paper, Shifting Treatment Perspectives in Polycythemia Vera: Real-World Experience with Ropeginterferon Alfa-2b, brings together perspectives from multidisciplinary oncology professionals to examine how ropeginterferon alfa-2b is being used in real-world practice and what may be influencing broader adoption.
Read the white paper to explore:
- How clinicians are thinking about the evolving role of ropeginterferon alfa-2b in PV
- Why access, workflow, and patient experience can influence treatment selection
- Practical strategies practices are using to support initiation and long-term management
- How medically integrated pharmacy and multidisciplinary care can help address implementation barriers
- What the newly approved BESREMi Pen™ may mean for administration and the patient experience
- Emerging evidence and the continued evolution of interferon-based therapy
See how multidisciplinary oncology teams are navigating the shift from treatment intent to real-world implementation in PV.
References
- Tefferi, Ayalew, Alessandro M. Vannucchi, and Tiziano Barbui. “Polycythemia Vera Treatment Algorithm 2018.” Blood Cancer Journal, vol. 8, no. 1, 2018, p. 3. Springer Nature, doi:10.1038/s41408-017-0042-7.
- Gisslinger, Heinz, et al. “Ropeginterferon Alfa-2b versus Standard Therapy for Polycythaemia Vera (PROUD PV and CONTINUATION-PV): A Randomised, Non-Inferiority, Phase 3 Trial and Its Extension Study.” The Lancet Haematology, vol. 7, no. 3, 2020, pp. e196–e208. Elsevier, doi:10.1016/S2352-3026(19)30236-4.
- Gisslinger, Heinz. Long-Term Use of Ropeginterferon Alpha-2b in Polycythemia Vera: 5-Year Results from a Randomized Controlled Study and Its Extension. American Society of Hematology (ASH) Annual Meeting, 2020, www.mpn-advocates.net/wp-content/uploads/2021/11/Heinz-Gisslinger-ASH2020-60-months-data_Template_13Nov2020.pdf. Accessed 5 May 2026.
- National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Myeloproliferative Neoplasms. NCCN, www.nccn.org. Accessed 26 Apr. 2026.
- PharmaEssentia USA. “PharmaEssentia Announces FDA Approval and U.S. Launch of BESREMi Pen (Ropeginterferon Alfa-2b-njft) for Polycythemia Vera.” PharmaEssentia USA, 26 June 2026, https://us.pharmaessentia.com/pharmaessentia-announces-fda-approval-and-u-s-launch-of-besremi-pen-ropeginterferon-alfa-2b-njft-for-polycythemia-vera/. Accessed 6 July 2026.
- ClinicalTrials.gov. “Low-PV: Ropeginterferon Alfa-2b in Low-Risk Polycythemia Vera.” U.S. National Library of Medicine, clinicaltrials.gov/study/NCT05481151. Accessed 26 Apr. 2026.
- Mesa, Ruben A., et al. “Ropeginterferon Alfa-2b in Hydroxyurea-Intolerant or Hydroxyurea-Refractory Essential Thrombocythaemia (SURPASS-ET): A Multicentre, Open-Label, Randomised, Active-Controlled, Phase 3 Study.” The Lancet Haematology, vol. 12, no. 11, 2025, pp. e862–e875. doi:10.1016/S2352-3026(25)00264-9.
- Reeves BN, El Chaer F, Foltz L, Tashi T, Abu-Zeinah G, Qin A, et al. Ropeginterferon alfa-2b-njft treatment in essential thrombocythemia across different driver mutations: results from a North American,
single-arm, multicentre study (EXCEED-ET). Lancet Regional Health – Americas. 2026;61:101529. - National Community Oncology Dispensing Association (NCODA). “Oncology Optimized Limited Distribution (OOLD).” NCODA, ncoda.org/oold/. Accessed 5 May 2026.