Fostamatinib (Tavalisse®) Use in Chronic Immune Thrombocytopenia

Fostamatinib is an oral spleen tyrosine kinase (Syk) inhibitor indicated for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment. ITP is mediated by platelet antibodies that accelerate platelet destruction and inhibit their production. Common treatments for ITP include corticosteroids, rituximab, IVIG, splenectomy, platelet infusion, and/or thrombopoietin receptor agonists. This PQI will review appropriate use of fostamatinib in this setting.