I am treating a patient with
Dose Modification Decision Charts
CLL
*GCSF can be considered in select patients depending on regimen
DOSE REDUCTIONS FOR TLS AND OTHER TOXICITIES
Dose at Interruption
Restart Dose
400mg
300mg
300mg
200mg
200mg
100mg
100mg
50mg
50mg
20mg
20mg
10mg
*Any dose interruption lasting more than 1 week during ramp up phase, or more than 2 weeks after completion of ramp up, reassess for TLS to determine if reinitiation with reduced dose is warranted
*Consider discontinuing venetoclax in patients who require dose reductions to < 100mg for more than 2 weeks
AML
*For Grade 3-4 non-hematologic toxicities, interrupt venetoclax if toxicity not resolved with supportive care. Upon resolution to Grade 1 or baseline, resume venetoclax at same dose.
*Bone marrow assessment recommended at the end of Cycle 1 to measure response. After achieving remission, treatment should be delayed until counts recover
CLL
![CLL Dose Modification Decision Chart](https://www.ncoda.org/wp-content/uploads/2023/01/CLL.png)
*GCSF can be considered in select patients depending on regimen
DOSE REDUCTIONS FOR TLS AND OTHER TOXICITIES | |||
Dose at Interruption | Restart Dose | ||
400mg | 300mg | ||
300mg | 200mg | ||
200mg | 100mg | ||
100mg | 50mg | ||
50mg | 20mg | ||
20mg | 10mg | ||
*Any dose interruption lasting more than 1 week during ramp up phase, or more than 2 weeks after completion of ramp up, reassess for TLS to determine if reinitiation with reduced dose is warranted | |||
*Consider discontinuing venetoclax in patients who require dose reductions to < 100mg for more than 2 weeks |
AML
![AML Dose Modification Decision Chart](https://www.ncoda.org/wp-content/uploads/2023/03/Screen-Shot-2023-03-08-at-7.38.03-AM.png)
*For Grade 3-4 non-hematologic toxicities, interrupt venetoclax if toxicity not resolved with supportive care. Upon resolution to Grade 1 or baseline, resume venetoclax at same dose.
*Bone marrow assessment recommended at the end of Cycle 1 to measure response. After achieving remission, treatment should be delayed until counts recover